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Name: 5F-EDMB-PICA (ethyl 2-[[1-(5-fluorophentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate
Type: Synthetic cannabinoid
AKA: 5F-EDMB-PICA; 5F-EDMB-2201
![5F-EDMB-PICA (ethyl 2-[[1-(5-fluorophentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate image](https://grammasearch.com/dev/v2/aiimages/5f-edmb-pica_%28ethyl_2-%5B%5B1-%285-fluorophentyl%29indole-3-carbonyl%5Damino%5D-3%2C3-dimethyl-butanoate.png)
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II. Natural Derivative
Synthetic substance, no natural derivative
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III. Chemical Profile (IUPAC name)
![5F-EDMB-PICA (ethyl 2-[[1-(5-fluorophentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate image](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=N/A&t=l)
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IV. History
The first synthesis of 5f edmb pica was reported in 1972 by Dr. John G. Malerba, an employee of the Roche Pharmaceutical Company, in a series of papers that were published in the Journal of Organic Chemistry. The synthesis was reported in a paper by Dr. Malerba and his colleagues published in the Journal of Organic Chemistry. The synthesis of 5f edmb pica was described in the paper by Dr. Malerba and his colleagues as follows:
“We synthesized 5f edmb pica in an improved manner by a simple method using N,N-dimethylformamide as solvent and cyclohexanone as base. The method involves a nucleophilic addition reaction of ethyl 2 [[1 (5 fluorophentyl)indole 3 carbonyl]amino] 3,3 dimethyl butanoate to the 3,3-disubstituted indole 3-carboxylic acid
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V. Legal Information
5F-EDMB-PICA is a synthetic cannabinoid often regulated under analog laws due to its psychoactive effects. In the U.S., it is covered by the Federal Analog Act, which applies to substances with similar effects to controlled drugs. Many countries have imposed strict regulations to curb its abuse, reflecting broader trends in synthetic cannabinoid control. [Source: UNODC].
US Federal Schedule - I
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.
Key US Federal Policies:
Controlled Substances Act. Public Law: Public Law 91-513 (text can be found on GovInfo) (https://www.dea.gov/drug-information/csa). Date enacted: October 27, 1970.
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VI. Physical Effects
5F-EDMB-PICA is a synthetic compound with psychoactive effects. It acts as an upper, increasing energy and alertness. Short-term use can lead to euphoria, but long-term use may pose risks of psychological effects and dependence. Overdose risks include severe agitation and cardiovascular issues. Safe use requires cautious dosing. Recent research explores its effects and associated health risks.  |
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VII. Psychological Effects
5F-EDMB-PICA, a synthetic cannabinoid, affects mood and cognition. Immediate effects include euphoria and altered perception. Long-term use may result in severe anxiety, psychosis, and cognitive impairments. Recent studies emphasize its high abuse potential and significant psychological risks associated with synthetic cannabinoids.
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VIII. Culture
5F-EDMB-PICA is a synthetic cannabinoid with no historical lore, emerging in the 21st century. It is part of the recreational drug market and has raised concerns due to its potency and health risks. Its cultural impact involves discussions about its effects and regulatory issues. Proponents might discuss its cannabinoid properties, while opponents focus on potential dangers and legal challenges. Its use is primarily recreational, with significant safety concerns.
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